牛远杰, 教授、主任医师,博士研究生导师。长期从事于前列腺癌的病因学研究。近五年围绕前列腺癌的激素非依赖性转化这一关键问题,通过研究前列腺癌内各类细胞中雄激素受体信号的不同调节作用,申请人的工作初步揭示了导致前列腺癌在雄激素阻断治疗后发生激素非依赖性转化的根本原因,阐明了雄激素阻断治疗可诱发前列腺癌进展和转移的机制,并得到国际同行认可。通过基因组学、蛋白组学和代谢组学研究,已初步筛选出国人激素非依赖性前列腺癌(CRPC)相关的分子信号通路。在此基础上,申请人拟采用细胞分子生物学方法鉴定和明确新的CRPC诊治标志物,初步研制可用于个体化治疗分型的诊断芯片和个体化治疗方案。近五年申请人发表SCI论文24篇,其中(共同)通讯作者论文/第一作者论文17篇。SCI累计影响因子为158,并被SCI文献引用321次。应邀编写英文专著2部。获国家科技进步一、二等奖各1项,天津市科技二等奖3项。

Yuanjie Niu, MD & Ph.D. Professor of surgery , chief physician and Dr. tutor.  Dr. Niu is Vice–President of Tianjin Institute of Urology. Professor & Director of the Department of Prostate Disease in Tianjin Institute of Urology, Tianjin Medical University. He has engaged in the etiology and translational medical research of prostate disease for 20 years . From 2004 to 2007, he studied in the U.S. University of Rochester as postdoctoral fellow. Now, he is engaging in researching the relationship between the etiology, metastasis , androgen-independent progression of prostate cancer and androgen receptor. Successively, he and collaborates obtained on 3 national research grants, 3 provincial research grants and other objects. He has published more than 100 papers including 40 SCI papers. He is specializing in the diagnosis and treatment of prostate disease in clinical work , especially the minimally invasive treatment.